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  6. RON/MST1R Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

RON/MST1R Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16887863 Shop All Proteintech Products
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150 μL
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20µL
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16887863 20 μL 20µL
16877863 150 μL 150µL
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Product Code. 16887863 Supplier Proteintech Supplier No. 110531AP20UL

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Description

Rabbit Polyclonal Antibody

Macrophage-stimulatin 1 receptor (MST1R/Ron), a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uteru.

Specifications

Antigen RON/MST1R
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene MST1R
Gene Accession No. Q04912, Q62190
Gene Alias CD136, CDw136, MSP receptor, MST1R, p185 Ron, Protein tyrosine kinase 8, PTK8, RON
Gene Symbols MST1R
Host Species Rabbit
Immunogen RON, MST1R Fusion Protein Ag1537
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19882, 300999, 4486
Target Species Human, Rat, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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