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Ro 67-7476, MedChemExpress

Product Code. 16444306
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Product Code. 16444306

Brand: Medchem Express HY100403

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Description

MedChemExpress Ro 67-7476 is a potent positive allosteric modulator of mGluR1 and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC50 of 60.1 nM. Ro 67-7476 is a potent P-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM).

Ro 67-7476 is a potent positive allosteric modulator of mGluR1 and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC50 of 60.1 nM. Ro 67-7476 is a potent P-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM).

Specifications

Chemical Name or Material Ro 67-7476
CAS 298690-60-5
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C17H18FNO2S
Quantity 100 mg
Solubility Information DMSO : ≥ 40 mg/mL (125.24 mM)
SMILES O=S(N1[C@H](C2=CC=C(F)C=C2)CCC1)(C3=CC=C(C)C=C3)=O
Molecular Weight (g/mol) 319.39
Formula Weight 319.39
Percent Purity 98.54%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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