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Tocris Bioscience™ Ro 31-8220 mesylate
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Product Code. 30001343
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10 mg
Unit Size:
10mg
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Product Code. 30001343 Supplier Tocris Bioscience™ Supplier No. 2002/10

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Description

Protein kinase inhibitor

Protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na+ channels in the micromolar range. Induces protein-protein interaction between mutant SMAD4R361H and SMAD3, leading to reactivation of dormant SMAD4R361H-mediated transcriptional activity and restoration of TGF-β-induced tumor suppression activity in SMAD4 mutant cancer cells.
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Specifications

CAS 138489-18-6
Quantity 10 mg
Molecular Formula C26H27N5O5S2
Formula Weight 553.65
Purity >97%
Molecular Weight (g/mol) 553.652
Chemical Name or Material Ro 31-8220 mesylate
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