Invitrogen™ RNF7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA557906

Product Code. 15705801

Description

Immunogen sequence: SLKKWNAVAM WSWDVECDTC AICRVQVMDA CLRCQAENKQ EDCVVVWGEC NHSFHNCCMS LWVKQNNRCP LCQQDWVVQR IGK Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Specifications

• Antigen: RNF7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF7
• Gene Alias: CKBBP1; CKII beta-binding protein 1; OTTHUMP00000180645; rbx2; Regulator of cullins 2; ring finger protein 7; RING-box protein 2; RNF7; ROC2; SAG; Sensitive to apoptosis gene protein; sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2; zinc RING finger protein SAG
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9616
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UBF6
• Gene Symbols: RNF7
• Immunogen: Recombinant protein corresponding to Human RNF7. Recombinant protein control fragment (Product #RP-96284).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG