Invitrogen™ RNF20 Recombinant Rabbit Monoclonal Antibody (SP00-47)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA542421

Product Code. 17789033

Description

Positive Control: Jurkat, MCF-7, Hela. Subcellular Location: Nucleus.

RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. RNF20 selectively suppresses the expression of some genes such as several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). In contrast, RNF20 also positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.

Specifications

• Antigen: RNF20
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q5DTM8, Q5VTR2
• Gene Symbols: RNF20
• Immunogen: Recombinant protein within human rnf20 aa 480-585.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Clone: SP00-47
• Conjugate: Unconjugated
• Gene: RNF20
• Gene Alias: 4833430L21Rik; AW540162; BRE1; BRE1 E3 ubiquitin ligase homolog; BRE1A; BRE1-A; C79397; E3 ubiquitin-protein ligase BRE1A; FLJ11189; FLJ20382; hBRE1; HNF3B; homolog of S. cerevisiae BRE1; hypothetical protein; KIAA2779; Kiaa4116; MGC129667; MGC129668; mKIAA4116; RCJMB04_5a23; RING finger protein 20; ring finger protein 20, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase BRE1A; Rnf20; TCF3B
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 109331, 56254
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid