Invitrogen™ RNF144B Monoclonal Antibody (OTI9H10)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA524997

Product Code. 15924604

Description

RNF144B Monoclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.

Specifications

• Antigen: RNF144B
• Classification: Monoclonal
• Concentration: 0.8 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q7Z419
• Gene Symbols: RNF144B
• Immunogen: Human recombinant protein fragment corresponding to amino acids 1-256 of RNF144B produced in E. coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: OTI9H10
• Conjugate: Unconjugated
• Gene: RNF144B
• Gene Alias: bA528A10.3; BC025007; E130105P19Rik; E3 ubiquitin-protein ligase RNF144B; IBR domain containing 2; IBR domain-containing protein 2; IBRDC2; p53-inducible RING finger protein; p53RFP; PIR2; RING finger protein 144B; Rnf144b
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 255488
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid