Invitrogen™ RNASE3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
17950563	Invitrogen™ PA5145280	20 μL
17980093	Invitrogen™ PA5145279	200 μL

Description

ECP (eosinophil cationic protein), also known as RNS3 or RNASE3 (ribonuclease, RNase A family, 3), is a 160 amino acid potent cytotoxic secretory protein that belongs to the pancreatic ribonuclease family. ECP localizes to the granule matrix of the eosinophil and is involved in the immune response system. ECP is a cytotoxin, neurotoxin and helminthotoxin that is secreted by activated human eosinophils. ECP exhibits anti-parasitic, antibacterial and ribonucleolytic activities. It has been suggested that ECP induces the neurotoxic effect known as the Gordon phenomenon, a syndrome manifested by ataxia, muscular rigidity, paralysis and tremor that may lead to death. ECP is considered a marker of eosinophilic inflammation and high levels have been found in cases of active asthma and other allergic diseases.

Specifications

• Antigen: RNASE3
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse
• Gene Accession No.: O35290
• Gene ID (Entrez): 53876
• Immunogen: Recombinant Mouse RNASE3 protein, Phe34-Val150 (Accession #O35290).
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

• Concentration: 0.5 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
• Gene Alias: cytotoxic ribonuclease; Ear11; EAR-11; Ear3; ECP; Eosinophil cationic protein; eosinophil cationic protein-like; eosinophil cationic-type ribonuclease 3; Eosinophil secondary granule ribonuclease 11; eosinophil-associated ribonuclease 3; eosinophil-associated, ribonuclease A family, member 3; LOC100361866; mR3; MR-3; murine ribonuclease 3; RAF1; Ribonuclease 3; ribonuclease A family member 3; ribonuclease, RNase A family 3; ribonuclease, RNase A family, 3; RNase 3; RNASE3; RNS3
• Gene Symbols: Ear3
• Isotype: IgG
• Purification Method: Antigen affinity chromatography, Protein A
• Gene: Ear3