Invitrogen™ RKHD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA595905

Product Code. 16598741

Description

Immunogen sequence: AGARRSSGAG TPRHSPTLPE PGGLRLELPL SRRGAPDPVG ALSWRPPQGP VSFPGGAAFS TATSLPSSPA AAACAPLDSG ASENSRKPPS ASSAPALARE C.

Rkhd1, also known as TINO or MEX3D is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd1, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd1 binds to the AU-rich element in the 3'-untranslated region of Bcl-2 mRNA and is thought to be a negative regulator of Bcl-2 expression. Rkhd3 and Rkhd4, but not Rkhd1, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.

Specifications

• Antigen: RKHD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mex3d
• Gene Alias: BC059858; bcl-2 ARE RNA binding protein; KIAA2031; MEX3; mex3 homolog D (C. elegans); mex-3 RNA binding family member D; Mex3d; MEX-3D; OK/SW-cl.4; ring finger (C3HC4 type) and KH domain containing 1; ring finger and KH domain containing 1; RING finger and KH domain-containing protein 1; RING finger protein 193; RKHD1; RNA-binding protein MEX3D; RNF193; TINO
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 237400
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.54 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q3UE17
• Gene Symbols: Mex3d
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 500-600 of human MEX3D (NP_9760493).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG