Invitrogen™ RIT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5111371

Product Code. 17109293

Description

Immunogen sequence: AYRYYIDDVF HALVREIRRK EKEAVLAMEK KSKPKNSVWK RLKSPFRKKK DSVT Highest antigen sequence indentity to the following orthologs: Mouse - 93%, Rat - 91%.

Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.

Specifica

• Antigen: RIT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RIT1
• Gene Alias: GTP-binding protein Rit1; GTP-binding protein Roc1; MGC125864; MGC125865; NS8; Ras like without CAAX 1; ras-like protein expressed in many tissues; Ras-like without CAAX 1; ras-like without CAAX protein 1; RGD1559874; RIBB; Ric-like, expressed in many tissues; RIT; RIT1; ROC1; si:ch211-93a2.3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6016
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q92963
• Gene Symbols: RIT1
• Immunogen: Recombinant Protein corresonding to Human RIT1. Recombinant protein control fragment (Product #RP-101351).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG