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Ristocetin Sulfate Salt, MP Biomedicals™
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Quantity:
25 mg
Description
Ristocetin A is structurally related to the glycopeptide antibiotics Teicoplanin and vancomycin. It activates platelets and has been used in platelet aggregation studies.
- Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis
- Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia
- Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes supporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals
- Studies have demonstrated that Ristocentin A dimerizes and creates two binding sites for cell wall peptides
Specifications
Specifications
Physical Form | Powder |
CAS | 1404-55-3 |
Molecular Formula | C95H112N8O48S |
Synonym | Ristomycin monosulfate |
Solubility Information | Soluble in 1 N HCl (50mg/mL - clear and colorless to pale yellow); soluble in water (clear 5mg+ 0.25mL, amber solution). |
InChI Key | HHRPQUHYQBGHHF-ADHWPEJWSA-N |
SMILES | CC1C(C(CC(O1)OC2C3C(=O)NC(C4=CC(=CC(=C4C5=C(C=CC(=C5)C(C(=O)N3)NC(=O)C6C7=CC(=C(C(=C7)OC8=CC=C2C=C8)OC9C(C(C(C(O9)COC1C(C(C(C(O1)C)O)O)O)O)O)OC1C(C(C(C(O1)CO)O)O)OC1C(C(C(CO1)O)O)O)OC1=CC=C(C=C1)C(C1C(=O)NC(C2=CC(=C(C(=C2)O)C)OC2=C(C=CC(=C2)C(C(=O)N1)N)O) |
Molecular Weight (g/mol) | 2166.009 |
PubChem CID | 46783382 |
Formula Weight | 2166.0 |
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