RIN1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16885994	Proteintech 16388-1-AP-20UL	20 μL
16875994	Proteintech 16388-1-AP-150UL	150 μL

Description

Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.

Specifications

• Antigen: RIN1
• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry, Immunofluorescence
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Human, Rat
• Gene Accession No.: P97680, Q13671, Q921Q7
• Gene ID (Entrez): 207119, 225870, 9610
• Immunogen: RIN1 Fusion Protein Ag9451
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: RIN1

• Concentration: 0.21 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: Ras and Rab interactor 1, Ras inhibitor JC99, RIN1
• Gene Symbols: RIN1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody