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Invitrogen™ RIM2 Polyclonal Antibody

Product Code. 12828702
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Quantity:
100 μg
Unit Size:
100µg
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12828702 100 μg 100µg
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Product Code. 12828702 Supplier Invitrogen™ Supplier No. PA520522

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-20522 can be used with blocking peptide PEP-0642.

Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RIM2
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Rims2
Gene Accession No. Q9EQZ7, Q9JIS1, Q9UQ26
Gene Alias 2810036I15Rik; AW048769; KIAA0751; mKIAA0751; Nim2; non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; OBOE; Rab3 interacting protein 1; Rab3 interacting protein 2; RAB3 interacting protein 3; Rab-3-interacting molecule 2; rab3-interacting molecule 2; Rab3-interacting protein; rab-3-interacting protein 2; rab3-interacting protein 2; Rab-3-interacting protein 3; Rab3ip2; RAB3IP3; regulating synaptic membrane exocytosis 2; regulating synaptic membrane exocytosis protein 2; RIM 2; Rim2; RIM2 (CT); Rim2(+40A); Rim2(+44A); Rim2(+4A); Rims2; Serg2; synaptic exocytosis regulator 2; synaptotagmin 3, related sequence; Syt3-rs
Gene Symbols Rims2
Host Species Rabbit
Immunogen A 17 amino acid peptide near the center of the human Rim2.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116838, 116839, 9699
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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