RIM2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA520522

Product Code. 12828702

Description

A suggested positive control is rat brain tissue lysate. PA5-20522 can be used with blocking peptide PEP-0642.

Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.

Specifications

• Antigen: RIM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rims2
• Gene Alias: 2810036I15Rik; AW048769; KIAA0751; mKIAA0751; Nim2; non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; OBOE; Rab3 interacting protein 1; Rab3 interacting protein 2; RAB3 interacting protein 3; Rab-3-interacting molecule 2; rab3-interacting molecule 2; Rab3-interacting protein; rab-3-interacting protein 2; rab3-interacting protein 2; Rab-3-interacting protein 3; Rab3ip2; RAB3IP3; regulating synaptic membrane exocytosis 2; regulating synaptic membrane exocytosis protein 2; RIM 2; Rim2; RIM2 (CT); Rim2(+40A); Rim2(+44A); Rim2(+4A); Rims2; Serg2; synaptic exocytosis regulator 2; synaptotagmin 3, related sequence; Syt3-rs
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116838, 116839, 9699
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q9EQZ7, Q9JIS1, Q9UQ26
• Gene Symbols: Rims2
• Immunogen: A 17 amino acid peptide near the center of the human Rim2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG