Rifabutin, 98%, Thermo Scientific Chemicals

Product Code.	Quantity	unitSize
15721769	1 g	1g
15731769	5 g	5g

Product Code. 15721769 Supplier Thermo Scientific Acros Supplier No. 461210010

Description

Rifabutin, CAS # 72559-06-09, is a broad-spectrum antibiotic with activity against mycobacteria, gram-positive and gram-negative bacteria.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Rifabutin is a compound with antibacterial activity most commonly used against Mycobacterium tuberculosis
• Rifabutin is a derivative of Rifamycin S that acts through blocking RNA polymerase subunit beta (RpoB)
• Rifabutin is an inducer as well as a substrate of CYP3A, a cytochrome P450 enzyme

Applications

• Rifabutin may be used in pharmacokinetic laboratory studies and high-throughput drug screens
• May be used in laboratory studies to determine drug resistance mutations present in Mycobacterium tuberculosis strains

Especificaciones

Identificadores de productos químicos

• CAS: 72559-06-9
• Molecular Formula: C46H62N4O11
• Molecular Weight (g/mol): 847.02
• MDL Number: MFCD00866816
• InChI Key: ATEBXHFBFRCZMA-VXTBVIBXSA-N
• Synonym: rifabutin, ansamycin, rifabutine, mycobutin, ansatipine, ansatipin, alfacid, rifabutina, rifabutinum, antibiotic lm 427
• PubChem CID: 57448257
• IUPAC Name: (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23,32-trioxo-8,33-dioxa-24,27,29-triazaspiro[pentacyclo[23.6.1.1⁴,⁷.0⁵,³¹.0²⁶,³⁰]tritriacontane-28,4'-piperidin]-1,3,5(31),9,19,21,25,29-octaen-13-yl acetate
• SMILES: CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C)C(O)=C4C(=O)C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)=C1NC5(CCN(CC(C)C)CC5)N=C1C4=C3C2=O

• Assay Percent Range: 97.5% min. (HPLC)
• Packaging: Glass Bottle
• Quantity: 1 g
• Formula Weight: 847
• Percent Purity: 98%
• Chemical Name or Material: Rifabutin

Seguridad y manipulación

Nombre del producto

• Rifabutin

Palabra de advertencia

• Warning

Clasificación

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Indicaciones de peligro

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Consejos de prudencia

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.

Otros peligros

• MIXTURE LIST-Contain: Rifabutin

RUO – Research Use Only