Invitrogen™ RICH2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA524152

Product Code. 13218478

Description

This antibody is predicted to react with rat based on sequence homology.

GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation. [UniProt].

Specifications

• Antigen: RICH2
• Classification: Polyclonal
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q17R89
• Gene Symbols: ARHGAP44
• Immunogen: KLH conjugated synthetic peptide between 784-811 amino acids from the C-terminal region of human RICH2.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Gene: ARHGAP44
• Gene Alias: ARHGAP44; KIAA0672; NPC-A-10; Rho GTPase activating protein 44; rho GTPase-activating protein 44; rho GTPase-activating protein RICH2; RhoGAP interacting with CIP4 homologs protein 2; Rho-type GTPase-activating protein RICH2; RICH2; RICH-2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 9912
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid