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Tocris™ Rhein

Product Code. 18768886
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10 mg
50 mg
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18768886 10 mg 10mg
18725986 50 mg 50mg
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Product Code. 18768886 Supplier Tocris™ Supplier No. 6867/10

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Description

FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3

Rhein is a FTO (mRNA N6-methyladenine demethylase) inhibitor (IC50 = 1.2 - 21 μM; Ki = 1.8 μM). Competitively binds enzyme at active site preventing binding of N6-methyladenosine (m6A) substrate and resulting in accumulation of DNA damage in cells. Also inhibits ALKBH3 and ALKBH2 (IC50 values are 5.3 and 9.1 μM, respectively). Sensitizes glioblastoma cells to alkylating agents. Active in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Quantity 10 mg
Molecular Formula C15H8O6
Formula Weight 284.22
Product Type Inhibitor
Purity 98%
Product Title
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