Invitrogen™ RGS21 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA562699

Product Code. 15730492

Description

Immunogen sequence: FPRFLKSEIY KKLVNSQQVP NHK Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 78%.

Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS21 is a recently identified member of this family that has been reported to be selectively expressed in subpopulations of taste bud cells and co-expressed with bitter and sweet transduction components such as alpha-gusticin, phospholipase Cbeta2, T1R2/T1R3 sweet taste receptors and T2R bitter taste receptors. Other reports indicate that RGS21 is more widely expressed. Binding assays demonstrate that RGS21 binds alpha-gusticin in a conformation-dependent manner and may do the same with T1R receptors, suggesting that RGS21 may play a role in sweet and bitter taste transduction processes.

Specifications

• Antigen: RGS21
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RGS21
• Gene Alias: EG624910; regulator of G-protein signaling 21; regulator of G-protein signalling 21; RGS21
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 431704
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q2M5E4
• Gene Symbols: RGS21
• Immunogen: Recombinant protein corresponding to Human RGS21. Recombinant protein control fragment (Product #RP-99839).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG