Invitrogen™ RGS18 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA583792

Product Code. 16360745

Description

Immunogen sequence: LFFSQINMCE SKEKTFFKLI HGSGKEETSK EAKIRAKEKR NRLSLLVQKP EFHEDTRSSR SGHLAKETRV SPEEAVKWGE S Highest antigen sequence indentity to the following orthologs: Rat - 78%, Mouse - 83%.

This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Specifications

• Antigen: RGS18
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RGS18
• Gene Alias: regulator of G-protein signaling 18; regulator of G-protein signalling 13; regulator of G-protein signalling 18; RGS13; RGS18; RP11-142L4.1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64407
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NS28
• Gene Symbols: RGS18
• Immunogen: Recombinant protein corresponding to Human RGS18. Recombinant protein control fragment (Product #RP-94313).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG