Invitrogen™ RGMA Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5114230

Product Code. 17192084

Description

Immunogen sequence: LPPAGDSQER SDSPEICHYE KSFHKHSAAP NYTHCGLFGD PHLRTFTDHF For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 93%; Dog: 86%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%.

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Specifications

• Antigen: RGMA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RGMA
• Gene Alias: BC059072; C230063O06; repulsive guidance molecule; repulsive guidance molecule A; repulsive guidance molecule family member a; RGM; RGM domain family member A; RGM domain family, member A; RGMA
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 244058
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q6PCX7
• Gene Symbols: RGMA
• Immunogen: Synthetic peptide directed towards the N-terminal region of mouse RGMA.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG