Retinoic Acid, All Trans Isomer, MP Biomedicals™

Description

Mediates the functions of vitamin A required for growth and development. Retinoic Acid, All Trans Isomer, MP Biomedicals has been used in various differentiation protocols, including B-cells, T cells and neurons, and is applied clinically to treat cancer

Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule. It affects gene transcription and modulates a wide variety of biological processes, including cell proliferation and differentiation, including apoptosis.

• Retinoic Acid mediated gene transcription depends on the rate of transport of Retinoic Acid to target cells and the timing of exposure of Retinoic Acid to RARs (Retinoic Acid Receptors) in the target tissues.
• All-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).
• The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells.
• Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA.
• Retinoic acid primes embryonic stem cells to become neurons.

Specifications

• Melting Point: 173°C to 183°C
• Quantity: 50 mg
• Solubility Information: Soluble in methanol, chloroform (40mg/mL) or acetone (30mg/mL), slightly soluble in ethanol.
• IUPAC Name: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
• Formula Weight: 300.4
• Physical Form: Powder

Safety and Handling

Product Identifier

• Retinoic Acid, All Trans Isomer

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 1
• Skin corrosion/irritation Category 2

Hazard Statement

• H300-Fatal if swallowed.
• H315-Causes skin irritation.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P321-Specific treatment (see on this label).
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P405-Store locked up.
• P501-Dispose of contents/container to in accordance with local/regional/national/international regulations..