RET (extracellular) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA5111870

Product Code. 17159783

Description

Reconstitute antibody with 50 μL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Peptide sequence is: CEWRQGDGKG ITR Homology: Mouse amino acid residues identical; rat - 12/13 amino acid residues identical.

RET is a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases which are cell-surface molecules that transduce signals for cell growth and differentiation. RET plays a crucial role in neural crest development, can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described for RET but their biological validity has not been confirmed.

Specifications

• Antigen: RET (extracellular)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RET
• Gene Alias: Cadherin family member 12; CDHF12; CDHR16; CG1061; CG14396; c-Ret; Dmel\CG14396; Dmel_CG14396; DmHD-59; DmRet; dret; D-ret; EC 2.7.10.1; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment; HD-59; HSCR1; kinase Ret; MEN2; MEN2A; MEN2B; MTC1; OTTHUMP00000216967; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; PTC; RET; RET51; RET9; RET-ELE1; Reto; Soluble RET kinase fragment
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19713, 24716, 5979
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunomicroscopy, Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 1% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: G3V9H8, P07949, P35546
• Gene Symbols: RET
• Immunogen: Peptide corresponding to amino acid residues 541-553 of human Ret (Extracellular, N-terminus)
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG