Invitrogen™ REPIN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5120641

Product Code. 17702044

Description

Positive test controls include: K-562, HeLa, Mouse testis, Mouse liver. Immunogen sequence: SCDDCGRSFR LERFLRAHQR QHTGERPFTC AECGKNFGKK THLVAHSRVH SGERPFACEE CGRRFSQGSH LAAHRRDHAP DRPFVCPDCG KAFRHKPYLA AHRRIHTGEK PYVCPDCGKA FSQKSNLVSH RRIHTGERPY ACPDCDRSFS QKSNLITHRK SHIRDGAFCC AICGQTFDDE ERLLAHQKKH DV.

Replication initiator 1 (REPIN1) is a gene encoding a zinc-finger protein that plays a critical role in various metabolic processes. Located on chromosome 7 in humans, REPIN1 is prominently expressed in liver and adipose tissues. It is associated with the regulation of body weight and triglyceride levels, as evidenced by its locus within a quantitative trait locus (QTL) related to these metabolic traits. The REPIN1 protein is involved in enhancing DNA bending, which is crucial for replication initiation. Studies have shown that deleting REPIN1 in the liver can lead to improved insulin sensitivity and altered lipid metabolism, with secondary effects on adipose tissue. Additionally, REPIN1 is implicated in iron metabolism and apoptosis regulation, further underscoring its multifaceted role in cellular processes.

Specifications

• Antigen: REPIN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: REPIN1
• Gene Alias: 60 kDa origin-specific DNA-binding protein; 60 kDa replication initiation region protein; AP4; ATT-binding protein; DHFR oribeta-binding protein RIP60; H_DJ0584D14.12; REPIN1; replication initiation region protein (60kD); replication initiator 1; RIP60; Zfp464; Zinc finger protein 464; zinc finger protein 464 (RIP60); zinc finger protein AP4; ZNF464
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29803, 58887
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 3.83 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q5U4E2, Q9BWE0
• Gene Symbols: REPIN1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 376-567 of human REPIN1 (NP_037532.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG