Invitrogen™ Renalase Recombinant Rabbit Monoclonal Antibody (9A5T7)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA538006

Product Code. 17226883

Description

Positive Samples: Mouse liver, Mouse testis, Mouse kidney, Rat liver, Rat testis, Rat kidney Immunogen sequence: MAQVLIVGAG MTGSLCAALL RRQTSGPLYL AVWDKAEDSG GRMTTACSPH NPQCTADLGA QYITCTPHYA KKHQRFYDEL LAYGVLRPLS SPIEGMVMKE.

Renalase is a flavoprotein enzyme encoded by the RNLS gene, primarily expressed in the kidneys and heart where it plays a critical role in metabolizing catecholamines and catecholamine-like substances. It utilizes nicotinamide adenine dinucleotide (NADH) as a cofactor and operates through a superoxide-dependent mechanism, which is distinct from monoamine oxidase pathways. Renalase is considered a novel renal hormone that influences blood pressure and cardiac function by regulating circulating catecholamines. Its genetic variants have been associated with essential hypertension, highlighting its importance in cardiovascular health. In diabetic nephropathy, renalase exhibits protective effects, as demonstrated in genetically modified mouse models. These models have shown that renalase overexpression can mitigate renal damage, suggesting therapeutic potential. Renalase's expression is highest in the proximal tubules of the kidneys, which are densely innervated by sympathetic nerves, underscoring the connection between renalase and sympathetic nervous system activity. This enzyme's discovery has enriched our understanding of renal hormone regulation and its implications in diseases such as chronic kidney disease (CKD) and end-stage renal disease (ESRD).

Specifications

• Antigen: Renalase
• Classification: Recombinant Monoclonal
• Concentration: 0.48 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: A7RDN6, Q5U2W9
• Gene Symbols: Rnls
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Renalase (Q5VYX0).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 9A5T7
• Conjugate: Unconjugated
• Gene: Rnls
• Gene Alias: 6530404N21Rik; AI452315; alpha-NAD(P)H oxidase/anomerase; AW060440; C10orf59; FLJ11218; HGNC:25641; MAO-C; mMAO-C; monoamine oxidase-C; Renalase; renalase, FAD dependent amine oxidase; renalase, FAD-dependent amine oxidase; RGD1309804; RNLS
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361751, 67795
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid