Invitrogen™ REG3G Polyclonal Antibody

Product Code.	Quantity	unitSize
17712194	100 μL	100µL

Product Code. 17712194 Supplier Invitrogen™ Supplier No. PA5120793

Description

Rabbit Polyclonal Antibody

Positive test controls include: BxPC-3, U-87MG, Rat skeletal muscle. The target is usually found in the following locations: Cytoplasm, Secreted. Immunogen sequence: EVAKKDAPSS RSSCPKGSRA YGSYCYALFS VSKNWYDADM ACQKRPSGHL VSVLSGAEAS FLSSMIKSSG NSGQYVWIGL HDPTLGYEPN RGGWEWSNAD VMNYINWETN PSSSSGNHCG TLSRASGFLK WRENYCNLEL PYVCKFKA.

REG3G, also known as regenerating islet-derived 3 gamma, is a gene encoding an antimicrobial peptide crucial for maintaining intestinal homeostasis and regulating host-microbiome interactions. The protein produced by REG3G belongs to the C-type lectin family and is primarily expressed in the gut, where it plays a significant role in defending against bacterial infections. REG3G helps maintain gut barrier function and immune responses, acting in collaboration with interleukin 22 (IL-22), which regulates its expression. This gene is downregulated during chronic ethanol exposure, suggesting an influence on susceptibility to alcoholic liver disease. REG3G is also involved in glucose metabolism, with evidence showing that its administration improves glucose tolerance, potentially through actions mediated by its receptor, Extl3. Furthermore, REG3G has been identified as a nociceptor-enriched hormone, which protects against endotoxic shock by modulating both local and systemic immunity. This diverse functionality underscores the gene's importance in immune modulation, gut physiology, and metabolic processes.

Specifications

• Antigen: REG3G
• Applications: ELISA, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 3.10 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: REG3G
• Gene Accession No.: O09049, P42854, Q6UW15
• Gene Alias: AI449515; generating islet-derived, mouse homolog 3 gamma; LPPM429; Pancreatitis-associated protein 1B; pancreatitis-associated protein 3; Pancreatitis-associated protein IB; PAP IB; PAP1B; PAP-1B; Pap3; PAPIB; PAPIII; REG III; Reg III-gamma; REG3G; REG3gamma; REG-3gamma; REG-3-gamma; regenerating family member 3 gamma; regenerating gene III; regenerating islet-derived 3 gamma; regenerating islet-derived protein 3 gamma; regenerating islet-derived protein 3-gamma; Regenerating islet-derived protein 3-gamma 15 kDa form; Regenerating islet-derived protein 3-gamma 16.5 kDa form; Regenerating islet-derived protein III-gamma; REG-III; RegIII (gamma); UNQ429; UNQ429/PRO162
• Gene Symbols: REG3G
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 27-174 of mouse REG3G (NP_0353901).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 130120, 19695, 24620
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG