Invitrogen™ RCCD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA559294

Product Code. 15777151

Description

Immunogen sequence: PFIAVQPFPA LLDLPMGSDA VKASCGSRHT AVVTRTGELY TWGWGKYGQL GHEDTTSLDR PRRVEYFVDK QLQVKAVTCG PWNTYVYAVE KG Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 85%.

Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8 (PubMed:24981860). Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8 (PubMed:28455245).

Specifications

• Antigen: RCCD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RCCD1
• Gene Alias: RCC1 domain containing 1; RCC1 domain-containing protein 1; RCCD1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 91433
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: A6NED2
• Gene Symbols: RCCD1
• Immunogen: Recombinant protein corresponding to Human RCCD1. Recombinant protein control fragment (Product #RP-98162).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG