missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. 12808842

Invitrogen™ RCAN2 Polyclonal Antibody

Product Code. 12808842
Change view
Click to view available options
Quantity:
100 μg
Unit Size:
100µg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
12808842 100 μg 100µg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Product Code. 12808842 Supplier Invitrogen™ Supplier No. PA520695

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Rabbit Polyclonal Antibody

A suggested positive control is NIH-3T3 cell lysate. PA5-20695 can be used with blocking peptide PEP-0810.

Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RCAN2
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Rcan2
Gene Accession No. Q14206, Q8CH27, Q9JHG2
Gene Alias calcineurin inhibitory protein ZAKI-4; Calcipressin-2; caskin-1-like; CSP2; Dcip2; Down syndrome candidate region 1-like 1; down syndrome candidate region 1-like protein 1; Down syndrome critical region gene 1-like 1; Down syndrome critical region gene 1-like 1 protein; Down syndrome critical region gene1-like 1; DSCR1L1; DSCR1L1 protein; LOW QUALITY PROTEIN: calcipressin-2; MCIP2; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2; Rcan2; RCN2; regulator of calcineurin 2; si:ch211-124g24.1; thyroid hormone-responsive (skin fibroblasts); thyroid hormone-responsive protein ZAKI-4; translation initiation factor IF-2; ZAKI4; ZAKI-4; zgc:85746
Gene Symbols Rcan2
Host Species Rabbit
Immunogen A 14 amino acid peptide near the center of human RCAN2.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10231, 140666, 53901
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.