Invitrogen™ RBM28 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA553909

Product Code. 15781841

Description

Immunogen sequence: RKLLLSATSG EKGVRIKECR VMRDLKGVHG NMKGQSLGYA FAEFQEHEHA LKALRLINNN PEIFGPLKRP IVEFSLEDRR KLKMKELRIQ RSLQKMRSKP ATGEPQKGQP EPAKDQQQK Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 82%.

Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.

Specifications

• Antigen: RBM28
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rbm28
• Gene Alias: 2810480G15Rik; AI503051; ANES; hypothetical protein MGC56258; RBM28; RNA binding motif protein 28; RNA-binding motif protein 28; RNA-binding protein 28; zgc:56258
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55131
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NW13
• Gene Symbols: Rbm28
• Immunogen: Recombinant protein corresponding to Human RBM28. Recombinant protein control fragment (Product #RP-92674).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG