Rb Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA5110276

Product Code. 17168203

Description

Sequence of this protein is as follows: RILVSIGESF GTSEKFQKIN QMVCNSDRVL KRSAEGSNPP KPLKKLRFDI EGSDEADGSK HLPGESKFQQ KLAEMTSTRT RMQKQKMNDS MDTSNKEEK

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Specifications

• Antigen: Rb
• Classification: Polyclonal
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P06400, P13405
• Gene Symbols: RB1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 830 to the C-terminus of human Rb (NP_000312.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunocytochemistry, Western Blot
• Conjugate: Unconjugated
• Gene: RB1
• Gene Alias: Cleaved Rb; delta RB-p70; DRb-p70; OSRC; p104; P105RB; p105-Rb; Phospho-Retinoblastoma; pp105; pp110; PPP1R130; pRb; Rb; RB1; Rb-1; Rb-p70; Retin; Retinoblastoma; Retinoblastoma-associated protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19645, 5925
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid