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STEMCELL Technologies Rat Recombinant M-CSF

Product Code. p-7217359
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Quantity:
25 μg
5 μg
Unit Size:
25µg
5µg
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Product Code. 17189601

Brand: STEMCELL Technologies 78117

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Description

Macrophage colony-stimulating factor

  • Macrophage colony-stimulating factor (M-CSF) is a homodimeric cytokine that belongs to receptor tyrosine kinase subclass III of the receptor tyrosine kinase (RTK) family
  • M-CSF acts on a CSF-1 receptor tyrosine kinase, which initiates signaling cascades to support cell proliferation and differentiation (Hamilton)
  • M-CSF is produced by endothelial cells, osteoblasts, and during pregnancy by the uterine epithelial cells (Ryan)
  • M-CSF synergizes with other factors to support proliferation and differentiation of multipotent hematopoietic progenitor cells, and regulates proliferation and differentiation of the mononuclear phagocyte progenitor cells to monocytes and macrophages
  • It also supports survival, proliferation, and function of the differentiated macrophages and regulates differentiation of mononuclear phagocytes to osteoclasts (Pixley & Stanley)
  • M-CSF plays an important role in the implantation of the embryo and early development (Makrigiannakis et al.)

Specifications

Name CSF-1, Macrophage colony-stimulating factor
Quantity 5 μg
Cell Type Hematopoietic Stem and Progenitor Cells; Monocytes
Purity or Quality Grade ≥95%
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