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Invitrogen™ IL-1 alpha Rat ELISA Kit

For the quantitative detection of rat IL-1alpha.

Brand:  Invitrogen™ BMS627TEN

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15592057

  • £1672.00 / Pack of 10


Estimated Shipment
21-07-2020
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Includes: Aluminium pouch(es) with a Microwell Plate coated with polyclonal antibody to rat IL-1alpha
Biotin-Conjugate anti-rat IL-1alpha polyclonal antibody
Streptavidin-HRP
Rat IL-1alpha Standard lyophilized, 2ng/mL upon reconstitution
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Specifications

Specifications

P16598
HRP
Biotin
24493
ELISA Kit
4.0 pg/mL
Serum, 50 μL|Supernatant, 50 μL
1 hr. 20 min.
Rat
Hematopoietin 1, IL1F1, Interleukin 1 alpha
5%
Rat
Colorimetric Microplate Reader
15.6-1,000 pg/mL
ELISA
Pre-coated 96 well plate, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
RUO
50 μL
2°C to 8°C
3 hr. 10 min.
IL-1 alpha
10%
10 x 96 Tests
Supernatant
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For Research Use Only