Gibco™ Rat IFN-alpha Recombinant Protein

Product Code. 10631124

Brand: Gibco™ PRC4014

Description

Recombinant Protein

Reconstitution: Dissolve the contents of the vial by injection of 150 μL sterile distilled water. Lyophilized product is stable for a defined length of time at -20°C. After reconstitution, the contents can be best divided into small aliquots for single use and stored at -80°C. After thawing, the cytokine is stable for at least four weeks at 4°C.

IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.

Specifications

• Accession Number: P05011
• For Use With (Application): Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot
• Formulation: Citric acid with 125mM trehalose and no preservative; pH 5
• Gene ID (Entrez): 298210, 298213
• Molecular Weight (g/mol): 19 kDa
• Name: Rat IFN-alpha
• pH Range: 5
• Purification Method: Purified
• Quantity: 1 x 10^5 units
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: ≤1 EU/vial
• Gene Alias: alpha-2a interferon; Gm12597; ifa; Ifa1; Ifa2; IFL; IFN; IFN alpha; IFN alpha 1/13; IFN alpha 1b; IFN α; IFN1@; IFNA; IFNA@; IFNA1; IFNA13; Ifna15; Ifna2; IFNA2A; IFNA2B; IFNA2C; IFNA3; IFNA6; Ifnaa; IFNAalphaIFN-alpha-1/13; IFNalpha; IFN-alpha; IFN-alpha 1b; IFN-alpha1; IFN-alpha-1; IFN-alpha-1/13; IFN-alpha-2; IFN-alpha-6; IFN-alphaA; IFN-alphaD; IFN-gamma; IFNα; INFA2; interferon; interferon alpha; interferon alpha 1; Interferon alpha 13 (IFNA13); interferon alpha 15; interferon alpha 1b; interferon alpha 2; interferon alpha 2a; interferon alpha 2b; interferon alpha A; interferon alpha family gene 1; interferon alpha family, gene 2; Interferon alpha leukocyte (IFL); interferon alpha protein; interferon alpha-1; Interferon alpha1 (IFNA1); interferon alpha-1 precursor; interferon alpha-1/13; Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-2; Interferon alpha-A; Interferon alpha-D; Interferon alpha-D (IFN alphaD); interferon type A1/A2; interferon type A3; interferon, alpha 1; interferon, alpha 2; interferon-alpha; interferon-alpha 1; interferon-alpha1; interferon-alpha-6; leIF A; LeIF D; MGC138207; MGC138505; MGC138507; MuIFN-alpha-A; novel interferon alpha (Ifna) family member; OTTMUSG00000007655
• Common Name: IFN alpha
• Gene Symbol: IFNA1, IFNA2
• Biological Activity: Specific Activity = 1x10e8 units/mg; one unit of activity is the amount of recombinant rat IFN-alpha that inhibits the cytopathic effect of VSV by 50% in monolayer cultures of Ratec cells grown in 96-well microtiter plates. Important Note: This recombinant rat IFN-alpha requires the presence of a reducing agent such as glutathione for full biological activity.
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Rat
• Recombinant: Recombinant
• Content And Storage: -20°C
• Activity: Specific Activity = 1x10e8 units/mg; one unit of activity is the amount of recombinant rat IFN-alpha that inhibits the cytopathic effect of VSV by 50% in monolayer cultures of Ratec cells grown in 96-well microtiter plates. Important Note: This recombinant rat IFN-alpha requires the presence of a reducing agent such as glutathione for full biological activity.
• Endotoxin Level: 1 EU/vial
• Shipping Condition: Approved for shipment on Wet or Dry Ice
• Expression System: Insect cells
• Protein Family: Cytokines & Receptors
• Protein Form: Recombinant, Ligand
• Form: Lyophilized
• Protein Subtype: Interferons
• Research Category: Immunology, Virology, Oncology, Signal Transduction
• Product Line: Gibco