NUP98, Rat, Clone: 2H10, Abnova™

Rat monoclonal antibody raised against partial recombinant NUP98.

Brand:  Abnova MAB6758.100ug

Product Code. 16120950

Description

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186kDa precursor protein. This cleavage results in the 98kDa nucleoporin as well as a 96kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq

Specifications

• Antigen: NUP98
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: The optimal working dilution should be determined by the end user.
• Gene: NUP98
• Gene Symbols: NUP98
• Immunogen: Recombinant GST fusion protein corresponding to amino acids 1-466 of human NUP98.
• Regulatory Status: RUO
• Gene ID (Entrez): 4928
• Content And Storage: Store at -20°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG2c κ

• Applications: Dot Blot, ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: 2H10
• Description: Rat monoclonal antibody raised against partial recombinant NUP98.
• Formulation: In PBS (50% glycerol, azide free)
• Gene Alias: ADIR2/NUP196/NUP96
• Host Species: Rat
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Form: Liquid