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Invitrogen™ RARB Monoclonal Antibody (R beta 28)
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Product Code. 11529942
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Quantity:
50 μg
Unit Size:
50µg
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Product Code. Quantity unitSize
11529942 50 μg 50µg
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Product Code. 11529942 Supplier Invitrogen™ Supplier No. MA1811

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Description

Mouse Monoclonal Antibody

MA1-811 detects retinoic acid receptor (RAR) beta from human and mouse tissues. This antibody cross-reacts slightly with RAR alpha when expressed in COS cells, though the level of signal on Western blots is very low relative to that seen with RAR beta. It does not detect RAR alpha or gamma from cell lines or tissue extract. MA1-811 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~52 kDa protein in rat tissue extract representing RAR beta. Also, by Western blot MA1-811 detects an unidentified ~120 kDa protein which can be competed away with the immunizing peptide. This protein is most notable in human SH-SY5Y and COS cells. Due to the extremely low levels of RAR expressed in native tissues, it is recommended that sensitive detection systems, such as enhanced chemiluminescence, be used. The MA1-811 immunogen is a synthetic peptide corresponding to the C-terminal sequence of mouse RAR beta. Reconstitute with PBS. MA1-811 can be used with blocking peptide PEP-005.

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RARB
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone R beta 28
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.05% sodium azide
Gene RARB
Gene Accession No. P10826, P22605
Gene Alias A830025K23; HAP; HBV-activated protein; hepatitis B virus activated protein; MCOPS12; NR1B2; nuclear receptor subfamily 1 group B member 2; RAR beta; Rarb; RAR-b; RAR-beta; RARbeta1; RAR-Beta2; RAR-Beta4; RAR-epsilon; retinoic acid; retinoic acid receptor; retinoic acid receptor beta; retinoic acid receptor, beta; retinoic acid receptor, beta polypeptide; RRB2
Gene Symbols RARB
Host Species Mouse
Immunogen Synthetic peptide corresponding to the C-terminal sequence of the mouse RAR beta.
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 218772, 24706, 5915
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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