Invitrogen™ RAPGEF5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA550106

Product Code. 15674035

Description

The antibody detects endogenous levels of total RAPGEF5 protein.

Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation. Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein that is expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse and rat. The gene that encodes Repac maps to human chromosome 7p15.3, with high expression of this region linking to positive response to erlotinib therapy for those with non-small-cell lung cancer.

Specifications

• Antigen: RAPGEF5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RAPGEF5
• Gene Alias: 4932413M22; C86120; D030051B22Rik; GFR; guanine nucleotide exchange factor; guanine nucleotide exchange factor for Rap1; KIAA0277; mKIAA0277; mmr-gef; Mras regulated guanine nucleotide exchange factor; M-Ras-regulated GEF; M-Ras-regulated Rap GEF; MRGEF; MR-GEF; Rap guanine nucleotide exchange factor (GEF) 5; Rap guanine nucleotide exchange factor 5; RAPGEF5; Related to Epac; REPAC; RGD1562891; rMR-GEF; tcag7.1034
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 217944, 9771
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8C0Q9, Q92565
• Gene Symbols: RAPGEF5
• Immunogen: Synthesized peptide derived from internal of human RAPGEF5.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG