Invitrogen™ RAP80 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA557979

Product Code. 15735871

Description

Immunogen sequence: LLRKAIAESL NSCRPSDASA TRSRPLATGP SSQSHQEKTT DSGLTEGIWQ LVPPSLFKGS HISQGNEAEE REEPWDHTEK TEEEPVSGSS G Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 77%.

RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.

Specifications

• Antigen: RAP80
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UIMC1
• Gene Alias: 9430016E08Rik; BRCA1-A complex subunit RAP80; D330018D10Rik; D630032M02Rik; RAP80; Receptor-associated protein 80; retinoid X receptor interacting protein 110; retinoid X receptor-interacting protein 110; RGD1307009; RIP110; Rxrip110; ubiquitin interaction motif containing 1; ubiquitin interaction motif-containing protein 1; Uimc1; X2HRIP110
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51720
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96RL1
• Gene Symbols: UIMC1
• Immunogen: Recombinant protein corresponding to Human RAP80. Recombinant protein control fragment (Product #RP-96860).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG