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Invitrogen™ RAP80 Polyclonal Antibody

Product Code. 12828472
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Quantity:
100 μg
Unit Size:
100µg
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12828472 100 μg 100µg
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Product Code. 12828472 Supplier Invitrogen™ Supplier No. PA520414

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Description

Rabbit Polyclonal Antibody

A suggested positive control is 293 cell lysate. PA5-20414 can be used with blocking peptide PEP-0531.

RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RAP80
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene UIMC1
Gene Accession No. Q5U5Q9, Q96RL1
Gene Alias 9430016E08Rik; BRCA1-A complex subunit RAP80; D330018D10Rik; D630032M02Rik; RAP80; Receptor-associated protein 80; retinoid X receptor interacting protein 110; retinoid X receptor-interacting protein 110; RGD1307009; RIP110; Rxrip110; ubiquitin interaction motif containing 1; ubiquitin interaction motif-containing protein 1; Uimc1; X2HRIP110
Gene Symbols UIMC1
Host Species Rabbit
Immunogen A 17 amino acid peptide from near the amino terminus of human RAP80.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20184, 51720
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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