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  6. Invitrogen™ RAP1GAP Recombinant Rabbit Monoclonal Antibody (K01_1X60)

Invitrogen™ RAP1GAP Recombinant Rabbit Monoclonal Antibody (K01_1X60)

Product Code. 30829918
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30825903 50 μL
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Product Code. 30829918 Supplier Invitrogen™ Supplier No. MA563465
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Estimated Shipment: 23-11-2026
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: CPEIKIQLEA SEQHMPQLG Highest antigen sequence identity to the following orthologs: Cynomolgus monkey - 100%.

Rap1GAP specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1. Physical interaction between G alpha z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the alpha subunit, and also attenuates the ability of activated G alpha z to inhibit adenylyl cyclase. Rap1GAP is expressed in the brain, kidney and pancreas and may act as a signal integrator to coordinate and/or integrate Gz signaling and Rap1 signaling in cells. A novel isoform of Rapl GTPase-activating protein, designated Rap1GAPII, binds specifically to G alpha z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases the amount of GTP-bound Rap1, resulting in the activation of ERK/MAPK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RAP1GAP
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone K01_1X60
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 150mM NaCl, 40% glycerol, 0.05% BSA and 0.01% sodium azide; pH 7.4
Gene RAP1GAP
Gene Accession No. A2ALS5, P47736
Gene Alias 1300019I11Rik; 2310004O14Rik; AI427470; ARPP-90; KIAA0474; RAP1 GTPase activating protein; Rap1 GTPase-activating protein; rap1 GTPase-activating protein 1; Rap1, GTPase-activating protein 1; Rap1ga1; Rap1GAP; Rap1GAP1; RAP1GAPII; RAPGAP
Gene Symbols RAP1GAP
Host Species Rabbit
Immunogen A synthetic peptide of human RAP1GAP (aa 644-662).
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 110351, 313644, 5909
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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