Invitrogen™ RAP Recombinant Rabbit Monoclonal Antibody (4)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA529399

Product Code. 16323464

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Human LRPAP1/A2MRAP.

The term RAP typically refers to receptor-associated protein, encoded by the LRPAP1 gene, which plays a significant role in the trafficking and function of certain receptors within cells. RAP is primarily involved in the regulation of low-density lipoprotein receptor-related proteins (LRPs) by acting as a chaperone during protein transport within the endoplasmic reticulum (ER). It prevents premature ligand binding and assists in the proper folding and assembly of receptor complexes, ensuring efficient receptor function and trafficking to the cell surface. RAP also influences cellular processes related to cholesterol metabolism and cell signaling through its interactions with these receptors. Its function is crucial for transporting and recycling receptors involved in various pathways, including lipid metabolism, endocytosis, and cellular homeostasis. Dysregulation of RAP or related receptor functions can impact metabolic health and are implicated in conditions such as atherosclerosis, neurodegenerative disorders, and cancer.

Specifications

• Antigen: RAP
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P30533
• Gene Symbols: Lrpap1
• Immunogen: Recombinant Human LRPAP1 protein (Tyr35-Leu357).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 4
• Conjugate: Unconjugated
• Gene: Lrpap1
• Gene Alias: 39 kDa receptor-associated protein; A2MRAP; A2RAP; AA617339; AI790446; Alpha-2-macroglobulin receptor-associated protein; Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin binding protein-44) (HBP-44); alpha-2-MRAP; AU042172; C77774; gp330-binding 45 kDa protein; HBP44; HBP-44; heparin-binding protein 44; LDL receptor related protein associated protein 1; low density lipoprotein receptor related protein, associated protein 1; low density lipoprotein receptor-related protein associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1); Lrpap1; MRAP; MYP23; RAP
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 4043
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid