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Invitrogen™ RANBP10 Polyclonal Antibody

Product Code. 12809082 Shop All Thermo Scientific Products
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Quantity:
100 μg
Unit Size:
100µg
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12809082 100 μg 100µg
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Produktkod. 12809082 Leverantör Invitrogen™ Leverantörsnummer PA520930

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Beskrivning

Rabbit Polyclonal Antibody

A suggested positive control is human skeletal muscle tissue lysate. PA5-20930 can be used with blocking peptide PEP-1044.

The RAN binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor that shares high sequence similarity to the MET-interacting protein RANBP9. RANBP10 is expressed in the cytoplasm of mature megakaryocytes (MKs) and platelets where it localizes to polymerized noncentrosomal microtubules. RANBP10 possesses guanine nucleotide exchange factor activity towards RAN, a GTPase involved in nucleocytoplasmic traffic, spindle formation at mitosis, and nuclear envelope assembly during telophase, suggesting that RANBP10 may also be involved in these activities. RANBP10 depletion in vitro caused the disturbance of polymerized filaments in MKs and platelets in RANBP10-null mice exhibited disorders in microtubule filament numbers and localization, indicating that RANBP10 may play a significant role in maintaining microtubule dynamics.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen RANBP10
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene RANBP10
Gene Accession No. Q6VN19, Q6VN20
Gene Alias 4432417N03Rik; KIAA1464; RAN binding protein 10; ran-binding protein 10; RANBP10; rangef; RGD1311587
Gene Symbols RANBP10
Host Species Rabbit
Immunogen A 15 amino acid peptide near the center of human RANBP10.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57610, 74334
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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