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RAD18 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA550025
Additional Details : Weight : 0.01000kg
Description
The antibody detects endogenous levels of total RAD18 protein.
Human Rad18 (hRad18) is homologue of the S. pombe Rad18 (3,4). In yeast, Rad6 and Rad18 play a crucial role in post-replication repair functions in gap-filling of a daughter strand on replication of damaged DNA (2). Furthermore, Rad6-Rad18 interaction is thought to be critical at an early step during lesion bypass in yeast. In vivo, Rad18 protein forms a tight complex with Rad6 through a conserved ring-finger motif (3,4). It has been suggested that Rad18-Rad6 complex binds to the damaged sites by the single-stranded DNA binding property of Rad 18. This is followed by degradation of the stalled components of DNA replication by ubiquitin-conjugating enzyme activity of Rad6 (1). The human Rad18 maps on chromosome 3p24-25, the region which is often deleted in lung, breast, ovary, and testis cancers. The human RAD18 gene codes for a protein of 495 amino acids with a predicted molecular weight of 56 kDa. The human Rad18 is ubiquitously expressed in various human tissues.Specifications
RAD18 | |
Polyclonal | |
Unconjugated | |
Rad18 | |
2810024C04Rik; E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; mRAD18Sc; postreplication repair protein hRAD18p; postreplication repair protein RAD18; post-replication repair protein RAD18SC; Rad18; RAD18 E3 ubiquitin protein ligase; RAD18 homolog; RAD18 homolog (S. cerevisiae); RAD18, E3 ubiquitin protein ligase; RAD18, S. cerevisiae, homolog; Rad18sc; RING finger protein 73; RING-type E3 ubiquitin transferase RAD18; RNF73 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
56852 | |
-20°C | |
Liquid |
Western Blot | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q9NS91 | |
Rad18 | |
Synthesized peptide derived from internal of human RAD18. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |