XAF1 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of XAF1.

Brand:  Abnova PAB13125.100ug

Product Code. 16070457

Description

X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001 [PubMed 11175744]).[supplied by OMIM

Specifications

• Antigen: XAF1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of XAF1.
• Formulation: In PBS (0.02% sodium azide)
• Gene Alias: BIRC4BP/HSXIAPAF1/XIAPAF1
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: Multiple isoforms of XAF-1 exist and a doublet at ∼30 KDa can be seen using anti-XAF-1 (IN).
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1-2 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: XAF1
• Gene Symbols: XAF1
• Immunogen: A synthetic peptide corresponding to internal region 16 amino acids of human XAF1.
• Regulatory Status: RUO
• Gene ID (Entrez): 54739
• Target Species: Human
• Form: Liquid

For Research Use Only