TERT Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of TERT.

Brand:  Abnova PAB18903.100ug

Product Code. 16073517

Description

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq

Specifications

• Antigen: TERT
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of TERT.
• Formulation: In buffer containing 0.02% sodium azide, 2% BSA
• Gene Alias: EST2/TCS1/TP2/TRT/hEST2
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

• Applications: ELISA, Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Dilution: ELISA (1:80000) Western Blot (1:200-1:500) Immunofluorescence (1:50) The optimal working dilution should be determined by the end user.
• Gene: TERT
• Gene Symbols: TERT
• Immunogen: A synthetic peptide corresponding to 14 amino acids at C-terminus of human TERT.
• Regulatory Status: RUO
• Gene ID (Entrez): 7015
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only