RFX5, Rabbit, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of RFX5.

Brand:  Abnova PAB11300.100ug

Product Code. 16029356

Description

A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75kDa subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq

Specifications

• Antigen: RFX5
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of RFX5.
• Formulation: In 20mM KH₂PO₄, 150mM NaCl, pH 7.2 (0.01% sodium azide)
• Gene Symbols: RFX5
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to amino acids 320-494 of human RFX5.
• Regulatory Status: RUO
• Gene ID (Entrez): 5993
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: ELISA, Gel Shift, Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1:1000) Gel Supershift assay (0.5-1.0 ul per assay) The optimal working dilution should be determined by the end user.
• Gene: RFX5
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

For Research Use Only