RELA Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of RELA.

Brand:  Abnova PAB12295.100ug

Product Code. 16213270

Description

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM

Specifications

• Antigen: RELA
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of RELA.
• Formulation: Lyophilized from 0.9mg NaCl, 0.2mg Na₂HPO₄ (5mg BSA, 0.05mg sodium azide, 0.05mg Thimerosal)
• Gene Accession No.: BC033522
• Gene Symbols: RELA
• Immunogen: A synthetic peptide corresponding to amino acids at N-terminus of human RELA.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: Identical to the related rat and mouse sequence.
• Content And Storage: Store at -20°C on dry atmosphere. After reconstitution with 200μL of deionized water to a concentration of 500μg/mL store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: RELA
• Gene Alias: MGC131774/NFKB3/p65
• Host Species: Rabbit
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 5970
• Target Species: Human
• Form: Lyophilized

For Research Use Only