RAF1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of RAF1.

Brand:  Abnova PAB7870.100uL

Product Code. 16060688

Description

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq

Specifications

• Antigen: RAF1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of RAF1.
• Formulation: In PBS (50% glycerol, 1mg/mL BSA, 0.05% sodium azide)
• Gene Alias: CRAF/NS5/Raf-1/c-Raf
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: This sequence is conserved in C-Rafs from many species, and is not found in A-Raf or B-Raf.
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Dilution: ELISA (1:2000) Western Blot (1:500) The optimal working dilution should be determined by the end user.
• Gene: RAF1
• Gene Symbols: RAF1
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to amino acids 637-648 of human RAF1.
• Regulatory Status: RUO
• Gene ID (Entrez): 5894
• Target Species: Human, Mouse, Rat
• Form: Liquid

For Research Use Only