PSEN2, Rabbit, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of PSEN2.

Brand:  Abnova PAB19096.100ug

Product Code. 16223720

Description

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq]

Specifications

• Antigen: PSEN2
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of PSEN2.
• Formulation: Lyophilized from 0.9mg NaCl, 0.2mg Na₂HPO₄ (5mg BSA, 0.05mg sodium azide, 0.05mg Thimerosal)
• Gene Alias: AD3L/AD4/PS2/STM2
• Host Species: Rabbit
• Purification Method: Immunoaffinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 5664
• Content And Storage: Store at -20°C on dry atmosphere. After reconstitution with 200μL of deionized water to a concentration of 500μg/mL store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL) Immunohistochemistry (Frozen sections) (1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: PSEN2
• Gene Symbols: PSEN2
• Immunogen: A synthetic peptide corresponding to internal region of human PSEN2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Form: Lyophilized

For Research Use Only