PAK4 (phospho S474), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of PAK4.

Brand:  Abnova PAB12642.100ug

Product Code. 16020017

Description

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq

Sequence: RKSLV

Specifications

• Antigen: PAK4
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of PAK4.
• Formulation: In TBS, pH 7.2 (BSA, 10% Proclin300)
• Gene Symbols: PAK4
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding S474 of human PAK4.
• Regulatory Status: RUO
• Gene ID (Entrez): 10298
• Target Species: Human, Mouse, Rat
• Form: Liquid

• Applications: ELISA, Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (0.1-1 ug/mL) ELISA (0.01-0.1 ug/mL) Immunoprecipitation (2-5 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: PAK4
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This antibody recognizes PAK4 at a phosphorylation site of Serine 474 (∼68KDa), or serine 602 of PAK5 (∼90KDa) or Serine 560 of PAK6 (∼80 KDa). It does not cross react to other PAK1, PAK2 or PAK3.
• Content And Storage: Store at 4°C. For long term storage store at -20°C or lower.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only