NOTCH2 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of NOTCH2.

Brand:  Abnova PAB10293.200uL

Product Code. 16099166

Description

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. [provided by RefSeq

Specifications

• Antigen: NOTCH2
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of NOTCH2.
• Formulation: In 20mM KH₂PO₄, 150mM NaCl, pH 7.2 (0.01% sodium azide)
• Gene Alias: AGS2/hN2
• Host Species: Rabbit
• Quantity: 200 μL
• Primary or Secondary: Primary
• Test Specificity: This antiserum is directed against human NOTCH 2. Based on sequences, we expect this antibody to react as well with rat and mouse NOTCH 2. Only one amino acid difference (conservative) occurs in mouse and rat. The immunogen epitope is only exposed after gamma secretase cleavage and is not accessible in the uncleaved form.
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: ELISA, Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Sandwich ELISA (1:30000-1:90000) The optimal working dilution should be determined by the end user.
• Gene: NOTCH2
• Gene Symbols: NOTCH2
• Immunogen: A synthetic peptide corresponding to N-terminus the cleaved N intracellular domain (NICD) of human NOTCH2.
• Regulatory Status: RUO
• Gene ID (Entrez): 4853
• Target Species: Human
• Form: Liquid

For Research Use Only