NOTCH1 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of NOTCH1.

Brand:  Abnova PAB12305.100ug

Product Code. 16243270

Description

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq

Specifications

• Antigen: NOTCH1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of NOTCH1.
• Formulation: Lyophilized from 0.9mg NaCl, 0.2mg Na₂HPO₄ (5mg BSA, 0.05mg sodium azide, 0.05mg Thimerosal)
• Gene Alias: TAN1/hN1
• Host Species: Rabbit
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 4851
• Target Species: Human
• Form: Lyophilized

• Applications: Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: NOTCH1
• Gene Symbols: NOTCH1
• Immunogen: A synthetic peptide corresponding to amino acids at internal region of human NOTCH1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: Different from the related rat sequence by one amino acid.
• Content And Storage: Store at -20°C on dry atmosphere. After reconstitution with 200μL of deionized water to a concentration of 500μg/mL store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG

For Research Use Only