NFKBIB Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of NFKBIB.

Brand:  Abnova PAB18763.100ug

Product Code. 16083367

Description

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM

Specifications

• Antigen: NFKBIB
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of NFKBIB.
• Formulation: In buffer containing 0.02% sodium azide
• Gene Alias: IKBB/TRIP9
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Dilution: ELISA (1:20000-1:80000) Western Blot (1:200-1:1000) The optimal working dilution should be determined by the end user.
• Gene: NFKBIB
• Gene Symbols: NFKBIB
• Immunogen: A synthetic peptide corresponding to 14 amino acids at C-terminus of human NFKBIB.
• Regulatory Status: RUO
• Gene ID (Entrez): 4793
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only