MMP12 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of MMP12.

Brand:  Abnova PAB25190.100uL

Product Code. 16085417

Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq

Specifications

• Antigen: MMP12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user.
• Gene: MMP12
• Gene Symbols: MMP12
• Immunogen: A synthetic peptide corresponding to MMP12.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: MMP12 polyclonal antibody detects endogenous levels of MMP12 protein.
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Concentration: 1 mg/mL
• Description: Rabbit polyclonal antibody raised against synthetic peptide of MMP12.
• Formulation: In PBS, pH 7.2 (0.05% sodium azide)
• Gene Alias: HME/MGC138506/MME
• Host Species: Rabbit
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 4321
• Target Species: Human
• Form: Liquid

For Research Use Only